Impact of Self-Induced Mutations on Skin Protein

Abstract

The human skin is the biggest organ in the body and serves as the body's first line of defence against external aggressions thanks to its strategic placement at the boundary between the interior and exterior.It is becoming more and more obvious that mutations in numerous cutaneous-associated keratin genes cause a variety of genetic skin diseases, each of which is characterised by compromised specific cell-tissue integrity, impairing the skin's capacity to function as a proper barrier and withstand repeated physical trauma. Several other concepts, including identity, similarity, and homology, are frequently (mis)used to describe sequence comparisons. Even though they are frequently used interchangeably, their meanings are very distinct. It is necessary to find the right alignment of two sequences before computing their similarity. The ability to recognise sequence similarity allows us to save countless biological years to apply knowledge of one sequence to other comparable sequences